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DOI 10.1002/ijc.70039

Медицинская библиотека · International journal of cancer · 2025

Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.

Moore Amy, Kane Eleanor, Teras Lauren R, Machiela Mitchell J, Arias Joshua, Panagiotou Orestis A, Monnereau Alain, Doo Nicole Wong, Wang Zhaoming, Slager Susan L, Vermeulen Roel C H, Vajdic Claire M, Smedby Karin E, Spinelli John J, Vijai Joseph, Giles Graham G, Link Brian K, Arslan Alan A, Nieters Alexandra, Bracci Paige M, Camp Nicola J, Salles Gilles, Cozen Wendy, Hjalgrim Henrik, De Vivo Immaculata, Adami Hans-Olov, Albanes Demetrius, Becker Nikolaus, Benavente Yolanda, Bisanzi Simonetta, Boffetta Paolo, Brennan Paul, Brooks-Wilson Angela R, Canzian Federico, Clavel Jacqueline, Conde Lucia, Cox David G, Curtin Karen, Foretova Lenka, Ghesquières Hervé, Glimelius Bengt, Habermann Thomas M, Hofmann Jonathan N, Lan Qing, Liebow Mark, Lincoln Anne, Maynadie Marc, McKay James, Melbye Mads, Miligi Lucia, Milne Roger L, Molina Thierry J, Morton Lindsay M, North Kari E, Offit Kenneth, Padoan Marina, Piro Sara, Patel Alpa V, Purdue Mark P, Ravichandran Vignesh, Riboli Elio, Severson Richard K, Southey Melissa C, Staines Anthony, Tinker Lesley F, Travis Ruth C, Wang Sophia S, Weiderpass Elisabete, Weinstein Stephanie, Zheng Tongzhang, Chanock Stephen J, Rothman Nathaniel, Birmann Brenda M, Cerhan James R, Berndt Sonja I

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Аннотация

Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.

Для цитирования: Moore Amy, Kane Eleanor, Teras Lauren R, Machiela Mitchell J, Arias Joshua, Panagiotou Orestis A, Monnereau Alain, Doo Nicole Wong, Wang Zhaoming, Slager Susan L, Vermeulen Roel C H, Vajdic Claire M, Smedby Karin E, Spinelli John J, Vijai Joseph, Giles Graham G, Link Brian K, Arslan Alan A, Nieters Alexandra, Bracci Paige M, Camp Nicola J, Salles Gilles, Cozen Wendy, Hjalgrim Henrik, De Vivo Immaculata, Adami Hans-Olov, Albanes Demetrius, Becker Nikolaus, Benavente Yolanda, Bisanzi Simonetta, Boffetta Paolo, Brennan Paul, Brooks-Wilson Angela R, Canzian Federico, Clavel Jacqueline, Conde Lucia, Cox David G, Curtin Karen, Foretova Lenka, Ghesquières Hervé, Glimelius Bengt, Habermann Thomas M, Hofmann Jonathan N, Lan Qing, Liebow Mark, Lincoln Anne, Maynadie Marc, McKay James, Melbye Mads, Miligi Lucia, Milne Roger L, Molina Thierry J, Morton Lindsay M, North Kari E, Offit Kenneth, Padoan Marina, Piro Sara, Patel Alpa V, Purdue Mark P, Ravichandran Vignesh, Riboli Elio, Severson Richard K, Southey Melissa C, Staines Anthony, Tinker Lesley F, Travis Ruth C, Wang Sophia S, Weiderpass Elisabete, Weinstein Stephanie, Zheng Tongzhang, Chanock Stephen J, Rothman Nathaniel, Birmann Brenda M, Cerhan James R, Berndt Sonja I. Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.. International journal of cancer. 2025. DOI: 10.1002/ijc.70039.

Предметные рубрики MeSH

HumansLymphoma, Large B-Cell, DiffuseBody Mass IndexMendelian Randomization AnalysisGenome-Wide Association StudyFemaleMaleMiddle AgedObesityMultifactorial InheritanceCase-Control StudiesPolymorphism, Single NucleotideWaist-Hip RatioGenetic Predisposition to DiseaseAdiposityLymphoma, FollicularLeukemia, Lymphocytic, Chronic, B-CellRisk Factors
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