Nature neuroscience · 2026
Base barrier cells provide compartmentalization of choroid plexus, brain and CSF.
СтатьяНазвание и аннотация: Перевод в очереди
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Verhaege Daan, De Nolf Clint, Van Acker Lore, Claeys Wouter, Castelein Jonas, Van Wonterghem Elien, Van Imschoot Griet, Dujardin Pieter, De Spiegelaere Ward, Hoste Esther, Boone Fleur, Lidov Hart G W, Dani Neil, Derk Julia, Kremer Anna, Van Hamme Evelien, Borghgraef Peter, Lippens Saskia, Lehtinen Maria K, Siegenthaler Julie, Van Hoecke Lien, Vandenbroucke Roosmarijn E
Аннотация
The choroid plexus (ChP), located in the brain ventricles, is largely composed of ChP epithelial cells that produce the cerebrospinal fluid (CSF) and form the blood-CSF barrier. At the ChP-brain attachment sites, we have discovered unique fibroblasts referred to as ChP base barrier cells (BBCs). We show that ChP BBCs originate from meningeal mesenchymal precursors, arrive early during development, remain throughout life and are conserved across species. ChP BBCs are transcriptionally similar to meningeal arachnoid barrier cells and are interconnected by both adherens and tight junctions. Notably, we provide evidence that the BBCs function as a barrier, controlling communication between the periphery and central nervous system. Moreover, during inflammatory insult, we observed a loss of barrier integrity and immune cell crossing. Altogether, our research revealed a barrier at the ChP base, crucial in protecting the central nervous system by compartmentalizing the ChP stroma, brain parenchyma and CSF.