Lakartidningen · 2023
[Factor XIII deficiency - not only a congenital bleeding disorder].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Liu Lijun, Song Lijun, Yang Qiu, Li Jiaxin, Qu Yi
Аннотация
OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with potential vascular complications. Ultrawide-field swept-source optical coherence tomography angiography (SS-OCTA) may serve as a non-invasive tool to assess retinal and choroidal microvasculature. We aimed to evaluate its utility in SLE for early detection and monitoring of SLE vasculopathy.
METHODS: 142 eyes of 71 SLE patients (median age 35 years, IQR 23-42) and 194 eyes of 97 healthy controls (median age 33 years, IQR 26-39.25) underwent ultrawide-field SS-OCTA imaging to quantify vascular density (VD) in retinal and choroidal layers. We collected clinical data, including disease activity scores (SLEDAI-2K), organ damage index (SDI), laboratory results, and treatment information (e.g. hydroxychloroquine dose).
RESULTS: Retinal and choroidal VD in SLE patients differed significantly from that of healthy controls (p<0.05). Disease duration and SLEDAI-2K scores correlated with microvasculature parameters, especially in mid-to-large choroidal vessels (MLCV). Longer disease duration (≥5 years) and higher cumulative hydroxychloroquine (HCQ) dose were associated with visual impairment. Deep retinal vessel density distinguished active disease.
CONCLUSIONS: Ultrawide-field SS-OCTA reveals distinct retinal and choroidal microvascular remodelling in SLE. MLCV density may serve as a marker for disease progression and HCQ exposure, supporting the potential of SS-OCTA for non-invasive monitoring of SLE-related vascular pathology.
METHODS: 142 eyes of 71 SLE patients (median age 35 years, IQR 23-42) and 194 eyes of 97 healthy controls (median age 33 years, IQR 26-39.25) underwent ultrawide-field SS-OCTA imaging to quantify vascular density (VD) in retinal and choroidal layers. We collected clinical data, including disease activity scores (SLEDAI-2K), organ damage index (SDI), laboratory results, and treatment information (e.g. hydroxychloroquine dose).
RESULTS: Retinal and choroidal VD in SLE patients differed significantly from that of healthy controls (p<0.05). Disease duration and SLEDAI-2K scores correlated with microvasculature parameters, especially in mid-to-large choroidal vessels (MLCV). Longer disease duration (≥5 years) and higher cumulative hydroxychloroquine (HCQ) dose were associated with visual impairment. Deep retinal vessel density distinguished active disease.
CONCLUSIONS: Ultrawide-field SS-OCTA reveals distinct retinal and choroidal microvascular remodelling in SLE. MLCV density may serve as a marker for disease progression and HCQ exposure, supporting the potential of SS-OCTA for non-invasive monitoring of SLE-related vascular pathology.