Auris, nasus, larynx · 2025
Retrospective study about suppression of new sensitization to cedar pollen in children who have undergone sublingual immunotherapy for house dust mites.
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Nagai Yuko, Obata Sho, Kawashima Kayoko, Kawabe Takanari, Hanada Yukiko, Yamaguchi Tomohiro, Ueno Rumi, Tsurinaga Yuki, Fukasawa Youhei, Takaoka Yuri, Yoshida Yukinori, Kameda Makoto
Аннотация
OBJECTIVE: To investigate whether sublingual immunotherapy (SLIT) with house dust mite (HDM) extract suppresses new sensitization to Japanese cedar pollen(JCP) in children with HDM-positive allergic rhinitis.
METHODS: This retrospective study was conducted at our center and included pediatric patients aged 5-15 years who visited between January 2018 and December 2020. Eligible patients tested positive for HDM-specific immunoglobulin E (IgE), negative for JCP-specific IgE, and had no history of SLIT for cedar pollen. 33 patients who continued HDM SLIT for 3 years were assigned to the SLIT group, while 52 patients with allergic rhinitis who did not receive HDM SLIT formed the non-SLIT group. Patients with severe allergic comorbidities or those undergoing immunosuppressive therapy were excluded. The primary endpoints were the rate of new sensitization to Japanese cedar pollen and the cedar-specific IgE levels after 3 years. We used the chi-square test, t-test, Mann-Whitney U test, and logistic regression analysis to compare the groups.
RESULT: After 3 years, the rate of new sensitization to JCP was 42.4 % in the SLIT group and 51.9 % in the non-SLIT group (p = 0.383). The JCP-specific IgE level was 4.77 UA/mL in the SLIT group and 7.93 UA/mL in the non-SLIT group (p = 0.207).
CONCLUSION: The SLIT group showed a slightly lower rate of new sensitization and lower JCP-specific IgE levels; however, the differences were not statistically significant. A larger, multi-center study is needed to confirm these findings and adjust for potential confounders.
METHODS: This retrospective study was conducted at our center and included pediatric patients aged 5-15 years who visited between January 2018 and December 2020. Eligible patients tested positive for HDM-specific immunoglobulin E (IgE), negative for JCP-specific IgE, and had no history of SLIT for cedar pollen. 33 patients who continued HDM SLIT for 3 years were assigned to the SLIT group, while 52 patients with allergic rhinitis who did not receive HDM SLIT formed the non-SLIT group. Patients with severe allergic comorbidities or those undergoing immunosuppressive therapy were excluded. The primary endpoints were the rate of new sensitization to Japanese cedar pollen and the cedar-specific IgE levels after 3 years. We used the chi-square test, t-test, Mann-Whitney U test, and logistic regression analysis to compare the groups.
RESULT: After 3 years, the rate of new sensitization to JCP was 42.4 % in the SLIT group and 51.9 % in the non-SLIT group (p = 0.383). The JCP-specific IgE level was 4.77 UA/mL in the SLIT group and 7.93 UA/mL in the non-SLIT group (p = 0.207).
CONCLUSION: The SLIT group showed a slightly lower rate of new sensitization and lower JCP-specific IgE levels; however, the differences were not statistically significant. A larger, multi-center study is needed to confirm these findings and adjust for potential confounders.