Combined neuroendocrine carcinoma of the penis: clinical, pathological and therapeutic insights.

Small-cell carcinomas of the genitourinary tract are high-grade neuroendocrine cancers with high metastatic potential. Penile cancer, though infrequent, is primarily squamous cell carcinomas.We report the second case of neuroendocrine cancer of the penis in a man in the seventh decade of life who presented with an enlarged area on the dorsum of the penis, clinical stage IV T1bN3M0 (tumour 1b, node 3, metastases 0).Neoadjuvant chemotherapy with cisplatin at 70 mg/m2 on day 1 (D1) and etoposide at 80 mg/m2 on D1-3 every 21 days, for three cycles was administered. Later, he underwent a partial penectomy. Consolidation with chemoradiotherapy employing weekly carboplatin (AUC of 2 mg/mL) was administered concurrently with 65 Gy radiation therapy to the bilateral iliac and inguinal nodes. The patient's CT shows no evidence of disease 48 months after completing the treatment.