Gan to kagaku ryoho. Cancer & chemotherapy · 2024
[Experience with Trastuzumab Deruxtecan for Brain Metastases of Breast Cancer].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Terakawa Hirofumi, Umemura Taichi, Kawata Chihiro, Kurokawa Yuki, Machi Ryosuke, Tanaka Hiroyuki, Nishimura Yuka, Mohri Ryosuke, Hirata Miki, Kitahara Tomomi, Moriyama Hideki, Kinoshita Jun, Kawashima Hiroko, Inaki Noriyuki
Аннотация
Breast cancer is a representative malignancy that is prone to brain metastasis. Recently, several studies have reported the efficacy of trastuzumab deruxtecan(T-DXd)in treating brain metastases. We have used T-DXd in 10 patients with brain metastases, and stereotactic or whole brain irradiation was performed in 9 of 10 patients. All patients had symptoms of brain metastases. Because T-DXd was administered in the late line in the early cases, symptoms due to brain metastases or meningeal dissemination worsened during T-DXd administration in a few cases. None of the four most recent cases showed worsening of brain metastasis or symptoms due to brain metastasis after T-DXd use. We would like to accumulate more cases and investigate whether T-DXd can be preferred over irradiation for asymptomatic patients with brain metastases.