Journal of pediatric hematology/oncology · 2022
Gonadotrophin-independent Precocious Puberty Secondary to an Estrogen Secreting Adrenal Tumor.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Tseretopoulou Xanthippi, Murray Matthew J, Buck Jackie, Hook C Elizabeth, Jackson Claire, Kosmoliaptsis Vasilis, Hughes Jacqueline, Gorman Samantha, Williams Rachel M
Аннотация
BACKGROUND: Adrenal masses are rare in children and most commonly present with clinical features of virilization in the absence of activation of the pituitary axis-gonadotrophin-independent precocious puberty.
OBSERVATIONS: We report an unusual case of a 7-year-old girl who presented with clinical signs suggestive of exposure to both androgens and estrogens. Imaging revealed a left-sided adrenal mass with no evidence of metastasis. She underwent successful laparoscopic unilateral adrenalectomy. Histology confirmed an adrenal adenoma.
CONCLUSION: We conclude that adrenocortical tumors should be considered in children presenting with gonadotrophin-independent precocious puberty and raised estrogens.
OBSERVATIONS: We report an unusual case of a 7-year-old girl who presented with clinical signs suggestive of exposure to both androgens and estrogens. Imaging revealed a left-sided adrenal mass with no evidence of metastasis. She underwent successful laparoscopic unilateral adrenalectomy. Histology confirmed an adrenal adenoma.
CONCLUSION: We conclude that adrenocortical tumors should be considered in children presenting with gonadotrophin-independent precocious puberty and raised estrogens.