Digestive diseases and sciences · 2015
A US Multicenter Study of Safety and Efficacy of Fully Covered Self-Expandable Metallic Stents in Benign Extrahepatic Biliary Strictures.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Saxena Payal, Diehl David L, Kumbhari Vivek, Shieh Frederick, Buscaglia Jonathan M, Sze Wilson, Kapoor Sumit, Komanduri Srinadh, Nasr John, Shin Eun Ji, Singh Vikesh, Lennon Anne Marie, Kalloo Anthony N, Khashab Mouen A
Аннотация
BACKGROUND: Endoscopic therapy is considered first line for management of benign biliary strictures (BBSs). Placement of plastic stents has been effective but limited by their short-term patency and need for repeated procedures. Fully covered self-expandable metallic stents (FCSEMSs) offer longer-lasting biliary drainage without the need for frequent exchanges.
AIMS: The aim of this study was to assess the efficacy and safety of FCSEMS in patients with BBS.
METHODS: A retrospective review of all patients who underwent ERCP and FCSEMS placement at five tertiary referral US hospitals was performed. Stricture resolution and adverse events related to ERCP and/or stenting were recorded.
RESULTS: A total of 123 patients underwent FCSEMS placement for BBS and 112 underwent a subsequent follow-up ERCP. The mean age was 62 years (±15.6), and 57% were males. Stricture resolution occurred in 81% of patients after a mean of 1.2 stenting procedures (mean stent dwell time 24.4 ± 2.3 weeks), with a mean follow-up of 18.5 months. Stricture recurrence occurred in 5 patients, and 3 patients required surgery for treatment of refractory strictures. Stent migration (9.7%) was the most common complication, followed by stent occlusion (4.9%), cholangitis (4.1%), and pancreatitis (3.3%). There was one case of stent fracture during removal, and one stent could not be removed. There was one death due to cholangitis.
CONCLUSIONS: Majority of BBS can be successfully managed with 1-2 consecutive FCSEMS with stent dwell time of 6 months.
AIMS: The aim of this study was to assess the efficacy and safety of FCSEMS in patients with BBS.
METHODS: A retrospective review of all patients who underwent ERCP and FCSEMS placement at five tertiary referral US hospitals was performed. Stricture resolution and adverse events related to ERCP and/or stenting were recorded.
RESULTS: A total of 123 patients underwent FCSEMS placement for BBS and 112 underwent a subsequent follow-up ERCP. The mean age was 62 years (±15.6), and 57% were males. Stricture resolution occurred in 81% of patients after a mean of 1.2 stenting procedures (mean stent dwell time 24.4 ± 2.3 weeks), with a mean follow-up of 18.5 months. Stricture recurrence occurred in 5 patients, and 3 patients required surgery for treatment of refractory strictures. Stent migration (9.7%) was the most common complication, followed by stent occlusion (4.9%), cholangitis (4.1%), and pancreatitis (3.3%). There was one case of stent fracture during removal, and one stent could not be removed. There was one death due to cholangitis.
CONCLUSIONS: Majority of BBS can be successfully managed with 1-2 consecutive FCSEMS with stent dwell time of 6 months.
Предметные рубрики MeSH
AgedBile Ducts, ExtrahepaticCholangiopancreatography, Endoscopic RetrogradeCholangitisCholestasisDevice RemovalDrainageFemaleForeign-Body MigrationHumansMaleMetalsMiddle AgedProsthesis DesignProsthesis FailureRecurrenceRetrospective StudiesRisk FactorsStentsTertiary Care CentersTime FactorsTreatment OutcomeUnited States