Science (New York, N.Y.) · 2026
Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain.
СтатьяНазвание и аннотация: Перевод в очереди
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Wu Haixu, Chen Duoyuan, Li Jun, Zhou Tao, Zhuang Zhenkun, Niu Zhiwei, Du Zeyu, Chen Yongjie, Chuan Shunqin, Xu Chunyan, Liao Xun, Meng Xiaoyu, Lu Jiali, Cui Wenxue, Lin Youning, Huang Fubaoqian, Liao Kuo, Liu Yan, Yang Tao, Chen Jing, Wang Hui, Dong Zhiqiang, Liu Longqi, Fang Xiaodong, Xu Xun, Li Qingwei, Pang Yue, Liu Shiping, Su Bing
Аннотация
The lamprey occupies a pivotal position for elucidating vertebrate brain evolution. Using spatial transcriptomics and single-nucleus RNA sequencing, we generated a three-dimensional molecular atlas of the lamprey brain, identifying 209 distinct cell clusters across 14 regions. Cross-species comparisons revealed broad conservation of regional spatial architecture, defining an ancestral organizational blueprint. Within this conserved framework, however, marked lineage-specific divergence emerged. We observed extensive neuronal specialization across vertebrate lineages, accompanied by regulatory shifts associated with spatial reorganization and functional diversification of neuronal populations. Additionally, our results suggest that a cerebellum-like architecture predates the jawed vertebrate cerebellum. Together, these findings identified constraints on neural organization and detected cellular innovations driving evolutionary diversification.