Ghrelin and gastrointestinal movement.

Ghrelin is a potent stimulant for gastric emptying and gastrointestinal (GI) movement. Clinically, it has been reported that the intravenous administration of ghrelin accelerates the rate of gastric emptying and induces gastric phase III contractions of the migrating motor complex in healthy volunteers. Recent technical advances in the measurement of GI motility in conscious small animals, including rats, mice, and the house musk shrew (Suncus murinus), have helped to elucidate the precise mechanism of action of ghrelin. Intravenous administration of ghrelin induces fasted motor activities with phase III-like contractions of the migrating motor complex in the antrum and duodenum in animals. These effects of ghrelin are mediated by activating the hypothalamic orexigenic neuropeptide Y neuron through ghrelin receptors located at the vagal afferent terminal. Stress hormone and anorexigenic peptides cause the disruption of fasted motor activity and induce fed-like motor activity. Ghrelin and the ghrelin signal potentiator rikkunshito successfully restore fed-like motor activities to fasted activities in fenfluramine-treated rats and in a cancer anorexia-cachexia animal model. These findings suggest that ghrelin can be expected to be a therapeutic target for GI disorders.