Potential Pitfall: Positive Follicular Lymphoma on [ 68 Ga]-PSMA-11 PET/CT for Prostate Cancer Staging.

Prostate-specific membrane antigen (PSMA)-targeted PET agents are a mainstay in staging high-risk prostate cancer. Nevertheless, PSMA expression is not exclusive to prostate cancer and is present in various neoplasms and inflammatory conditions. We report a case of biopsy-proven follicular lymphoma positive on PSMA PET/CT originally performed for staging of prostate cancer in a 66-year-old patient. This case highlights the potential pitfall of lymphoma mimicking prostate cancer nodal metastasis on PSMA PET/CT and the importance of careful evaluation of distribution and uptake of lymph nodes when assessing PSMA PET/CT studies to distinguish lymphoma from prostate cancer metastases.