Molecular biology reports · 2026
SLCO1B1 and MTRR gene variants in pediatric acute lymphoblastic leukemia: a study on Egyptian children.
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Mahdi Ali Nabeel, Elsaid Afaf M, Mohammed Maha Abdelmoneim, Madkour Mai M, Abdel-Aziz A F
Аннотация
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common malignancy in pediatric populations and affects white blood cells. The solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene encodes the organic anion transporting polypeptide 1B1 (OATP1B1), a transporter involved in drug metabolism, whereas methionine synthase reductase (MTRR) plays an essential role in DNA synthesis and methylation. This study investigated the association between pediatric ALL and genetic polymorphisms in the SLCO1B1 and MTRR genes in an Egyptian population.
METHODS: Tetra-primer amplification refractory mutation polymerase chain reaction (T-ARMS-PCR) was used to genotype the SLCO1B1 (521T > C, rs4149056) and MTRR (1049 A > G, rs162036) variants in 100 pediatric ALL patients and 100 healthy controls.
RESULTS: Significant differences in genotype and allele frequencies were observed between cases and controls for both variants (SLCO1B1: p = 0.001; MTRR: p = 0.001 and p = 0.04, respectively).
CONCLUSIONS: These findings suggest a possible association between SLCO1B1 and MTRR polymorphisms and susceptibility to pediatric ALL in the studied Egyptian population.
METHODS: Tetra-primer amplification refractory mutation polymerase chain reaction (T-ARMS-PCR) was used to genotype the SLCO1B1 (521T > C, rs4149056) and MTRR (1049 A > G, rs162036) variants in 100 pediatric ALL patients and 100 healthy controls.
RESULTS: Significant differences in genotype and allele frequencies were observed between cases and controls for both variants (SLCO1B1: p = 0.001; MTRR: p = 0.001 and p = 0.04, respectively).
CONCLUSIONS: These findings suggest a possible association between SLCO1B1 and MTRR polymorphisms and susceptibility to pediatric ALL in the studied Egyptian population.