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DOI 10.6004/jnccn.2021.0054

Медицинская библиотека · Journal of the National Comprehensive Cancer Network : JNCCN · 2021

NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021.

Zelenetz Andrew D, Gordon Leo I, Chang Julie E, Christian Beth, Abramson Jeremy S, Advani Ranjana H, Bartlett Nancy L, Budde L Elizabeth, Caimi Paolo F, De Vos Sven, Dholaria Bhagirathbhai, Fakhri Bita, Fayad Luis E, Glenn Martha J, Habermann Thomas M, Hernandez-Ilizaliturri Francisco, Hsi Eric, Hu Boyu, Kaminski Mark S, Kelsey Christopher R, Khan Nadia, Krivacic Susan, LaCasce Ann S, Lim Megan, Narkhede Mayur, Rabinovitch Rachel, Ramakrishnan Praveen, Reid Erin, Roberts Kenneth B, Saeed Hayder, Smith Stephen D, Svoboda Jakub, Swinnen Lode J, Tuscano Joseph, Vose Julie M, Dwyer Mary A, Sundar Hema

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Аннотация

In the last decade, a better understanding of the molecular pathogenesis of B-cell non-Hodgkin lymphomas has resulted in the development of novel targeted therapies, such as small molecule inhibitors of select kinases in the B-cell receptor pathway, antibody-drug conjugates, and small molecules that target a variety of proteins (eg, CD-19, EZH2, and XPO-1-mediated nuclear export). Anti-CD19 CAR T-cell therapy, first approved for relapsed/refractory (R/R) diffuse large B-cell lymphoma, has also emerged as a novel treatment option for R/R follicular lymphoma and mantle cell lymphoma. These NCCN Guideline Insights highlight the new targeted therapy options included in the NCCN Guidelines for B-Cell Lymphomas for the treatment of R/R disease.

Для цитирования: Zelenetz Andrew D, Gordon Leo I, Chang Julie E, Christian Beth, Abramson Jeremy S, Advani Ranjana H, Bartlett Nancy L, Budde L Elizabeth, Caimi Paolo F, De Vos Sven, Dholaria Bhagirathbhai, Fakhri Bita, Fayad Luis E, Glenn Martha J, Habermann Thomas M, Hernandez-Ilizaliturri Francisco, Hsi Eric, Hu Boyu, Kaminski Mark S, Kelsey Christopher R, Khan Nadia, Krivacic Susan, LaCasce Ann S, Lim Megan, Narkhede Mayur, Rabinovitch Rachel, Ramakrishnan Praveen, Reid Erin, Roberts Kenneth B, Saeed Hayder, Smith Stephen D, Svoboda Jakub, Swinnen Lode J, Tuscano Joseph, Vose Julie M, Dwyer Mary A, Sundar Hema. NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021.. Journal of the National Comprehensive Cancer Network : JNCCN. 2021. DOI: 10.6004/jnccn.2021.0054.

Предметные рубрики MeSH

AdultAntigens, CD19HumansImmunoconjugatesImmunotherapy, AdoptiveLymphoma, Large B-Cell, DiffuseLymphoma, Non-Hodgkin
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