Bratislavske lekarske listy · 2024
Modeling brain pathology to study nose-to-brain drug delivery.
СтатьяНазвание и аннотация: Перевод в очереди
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Talgatkyzy Аltynay, Khaibullin Talgat, Syzdykbayev Marat, Kazymov Maksut, Sharapiyeva Alua, Amrenova Kuralay, Dinara Shagiyeva, Тoktabayeva Вakytkul, Khamitova Meruyert, Apsalikov Bakytbek, Ozhmukhametova Elvira
Аннотация
OBJECTIVES: To create a new mucoadhesive dosage form based on PluronicF127 followed by transformation into a gel form upon intranasal administration for targeted delivery to brain tissueMETHODS: Citicoline, cytidine diphosphocholine, designated as CDP-choline, was purchased as a white powder with the molecular weight of 510.31 g/mol. The triblock copolymers of polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (PEG-PPG-PEG), branded as Pluronic F127, was used.
RESULTS: When instilled into the nasal cavity, Pluronic F127 for intranasal administration is transformed into a gel that remains retained for 45-55 minutes, which promotes better penetration of drugs into the brain tissue.
CONCLUSION: The polymer's gelling and adhesive properties performed well, which is crucial for further research at the preclinical stage (Tab. 1, Fig. 5, Ref. 28).
RESULTS: When instilled into the nasal cavity, Pluronic F127 for intranasal administration is transformed into a gel that remains retained for 45-55 minutes, which promotes better penetration of drugs into the brain tissue.
CONCLUSION: The polymer's gelling and adhesive properties performed well, which is crucial for further research at the preclinical stage (Tab. 1, Fig. 5, Ref. 28).