Journal of occupational and environmental medicine · 2025
Polybrominated Diphenyl Ethers, Occupational Exposures, and Thyroid Function Among US and Canadian Firefighters: A Cross-sectional Study.
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Gould Rothberg Bonnie E, Caban-Martinez Alberto J, Barr Dana Boyd, Jara Mark A, Rodriguez Valentina, Louzado Feliciano Paola, Santiago Katerina M, Campos Beaver Cynthia, Kobetz-Kerman Erin N, Schaefer Solle Natasha
Аннотация
OBJECTIVE: Evaluate the association between serum polybrominated diphenyl ether (PBDE) levels and thyroid anatomy and function in firefighters.
METHODS: Two hundred fifty-nine firefighters provided a blood sample and underwent thyroid ultrasound. Blood serum levels were tested for thyroid function tests and PBDEs -47, -85, -99, -100, -153, and -154 (ng/g lipid weight). Ultrasonography documented structural characteristics. Bivariate associations between PBDE concentrations and demographic/occupational characteristics, thyroid function, and thyroid anatomic measures were determined using multivariable linear regression.
RESULTS: A positive relationship between PBDE-47 and triiodothyronine ( P = 0.02) while an inverse relationship with free thyroxine ( P = 0.03) was observed. PBDE-47 was inversely associated with thyroid nodule size ( P = 0.03) and nodule aggressiveness ( P = 0.02). PBDE-47 was highest in western United States firefighters and lowest among sampled Canadians ( P = 0.01).
CONCLUSIONS: PBDE-47 may contribute to thyroid dysregulation in firefighters. PBDE-47 levels differ across North America.
METHODS: Two hundred fifty-nine firefighters provided a blood sample and underwent thyroid ultrasound. Blood serum levels were tested for thyroid function tests and PBDEs -47, -85, -99, -100, -153, and -154 (ng/g lipid weight). Ultrasonography documented structural characteristics. Bivariate associations between PBDE concentrations and demographic/occupational characteristics, thyroid function, and thyroid anatomic measures were determined using multivariable linear regression.
RESULTS: A positive relationship between PBDE-47 and triiodothyronine ( P = 0.02) while an inverse relationship with free thyroxine ( P = 0.03) was observed. PBDE-47 was inversely associated with thyroid nodule size ( P = 0.03) and nodule aggressiveness ( P = 0.02). PBDE-47 was highest in western United States firefighters and lowest among sampled Canadians ( P = 0.01).
CONCLUSIONS: PBDE-47 may contribute to thyroid dysregulation in firefighters. PBDE-47 levels differ across North America.