Intronic Single Nucleotide Polymorphisms in FGFR2 Gene Association With Non-Syndromic Mandibular Retrognathism.

OBJECTIVE

Mandibular retrognathism (MR) is a skeletal malocclusion in which patients have a deficient mandibular length, resulting in a more posterior position of the mandible. We aimed to investigate the association between Single nucleotide polymorphisms (SNPs) in Fibroblast Growth Factor Receptor 2 (FGFR2) gene and MR in germans.

MATERIALS AND

METHODS

Genomic DNA and lateral cephalometric radiographs were obtained from orthodontic patients. Patients were allocated into the 'Retruded' group (SNB angle < 78°) and into the 'Well-positioned' group (SNB 78°-82°). The rs4752566, rs10736303, rs11200014, rs1078806, rs1219648, rs2981578 and rs2162540 SNPs were genotyped using real-time PCR. Allele, genotype and haplotype frequencies were compared (α = 5%).

RESULTS

A total of 142 patients were included, 93 (65.5%) allocated into the 'Retruded' group and 49 (34.5%) into the 'Well-positioned' group. The allele T in rs2981578 SNP was statistically more frequent in the 'Retruded' group in both univariate (PR = 1.22; 95% CI, = 1.02-1.47) and multivariate (PR = 1.55; 95% CI, = 1.07-2.25) analyses (p < 0.05). The CT + TT genotypes were statistically more frequent in the 'Retruded' group in univariate (PR = 1.58; 95% CI, = 1.03-2.41) and multivariate (PR = 1.59; 95% CI, = 1.11-2.26) analysis (p < 0.05). All studied SNPs were associated with MR establishment in haplotype analysis (p < 0.05).

CONCLUSION

SNPs in the FGFR2 are associated with MR and have the potential to serve as genetic biomarkers to early diagnosis and prediction of mandible growth.