MedElevator
Войти в исследования Journal of global antimicrobial resistance · 2025
30-d mortality risk factors in paediatric patients with bloodstream infection due to Enterobacterales: A retrospective observational cohort study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Karla Ojeda-Diezbarroso, Rodolfo Norberto Jimenez-Juarez, Martha Avilés-Robles, Almudena Laris-González, Sergio Bonilla-Pellegrini, Liliana Pichardo-Villalón, Carmen Castellanos-Cruz
Аннотация
OBJECTIVE: Data on paediatric bloodstream infection (BSI) in low- and middle-income countries remain scarce. Consequently, this study aims to elucidate the risk factors associated with mortality in paediatric patients with enterobacterial BSIs.
METHODS: This was a retrospective analysis of patients with bloodstream infection due to Enterobacterales attended at Hospital Infantil de Mexico during 2013-2019. Factors influencing mortality were assessed. The baseline characteristics of the population, bloodstream infection and antimicrobial treatment were compared between survivors and non-survivors as well.
RESULTS: Of 527 cases of BSIs, 63.6% (n = 335) were caused by Enterobacterales and 307 cases were included. The overall mortality rate was 11.1% (n = 34). In the multivariable regression model, septic shock/multiorgan failure (HR 9.69, 95% CI: 3.28-28.63), and empirical treatment failure (HR 3.4, 95% CI: 1.36-8.45) were associated with an increased mortality risk.
CONCLUSIONS: in this study, the mortality in paediatric BSIs was driven by severe clinical presentation and failure to control inflammatory response and infection. Improving outcomes requires proactive measures, including early detection of sepsis by caregivers, education of healthcare providers for timely recognition and treatment, vigilant monitoring of systemic inflammatory response with adaptable therapeutic approaches and reinforcement of antimicrobial stewardship programs.
METHODS: This was a retrospective analysis of patients with bloodstream infection due to Enterobacterales attended at Hospital Infantil de Mexico during 2013-2019. Factors influencing mortality were assessed. The baseline characteristics of the population, bloodstream infection and antimicrobial treatment were compared between survivors and non-survivors as well.
RESULTS: Of 527 cases of BSIs, 63.6% (n = 335) were caused by Enterobacterales and 307 cases were included. The overall mortality rate was 11.1% (n = 34). In the multivariable regression model, septic shock/multiorgan failure (HR 9.69, 95% CI: 3.28-28.63), and empirical treatment failure (HR 3.4, 95% CI: 1.36-8.45) were associated with an increased mortality risk.
CONCLUSIONS: in this study, the mortality in paediatric BSIs was driven by severe clinical presentation and failure to control inflammatory response and infection. Improving outcomes requires proactive measures, including early detection of sepsis by caregivers, education of healthcare providers for timely recognition and treatment, vigilant monitoring of systemic inflammatory response with adaptable therapeutic approaches and reinforcement of antimicrobial stewardship programs.