Ультразвуковая спектроскопическая съемка магнитного резонанса для метаболической съемки мозга с высоким разрешением.
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Zhao Yibo, Li Yudu, Jin Wen, Guo Rong, Ma Chao, Tang Weijun, Li Yao, El Fakhri Georges, Liang Zhi-Pei
Аннотация
Оригинал публикации
Ultrafast J-resolved magnetic resonance spectroscopic imaging for high-resolution metabolic brain imaging.
Magnetic resonance spectroscopic imaging has potential for non-invasive metabolic imaging of the human brain. Here we report a method that overcomes several long-standing technical barriers associated with clinical magnetic resonance spectroscopic imaging, including long data acquisition times, limited spatial coverage and poor spatial resolution. Our method achieves ultrafast data acquisition using an efficient approach to encode spatial, spectral and J-coupling information of multiple molecules. Physics-informed machine learning is synergistically integrated in data processing to enable reconstruction of high-quality molecular maps. We validated the proposed method through phantom experiments. We obtained high-resolution molecular maps from healthy participants, revealing metabolic heterogeneities in different brain regions. We also obtained high-resolution whole-brain molecular maps in regular clinical settings, revealing metabolic alterations in tumours and multiple sclerosis. This method has the potential to transform clinical metabolic imaging and provide a long-desired capability for non-invasive label-free metabolic imaging of brain function and diseases for both research and clinical applications.