Decreased plasma visfatin concentrations in pediatric aneurysmal bone cyst: a pilot study.

OBJECTIVE

This is a prospective study and visfatin values of patients with aneurysmal bone cysts (ABC) were compared with those of healthy individuals.

METHOD: This study consists of 20 patients diagnosed with ABC (Group 1) and 30 healthy patients (Group 2). Age, gender, cyst sizes, and visfatin values of all patients were recorded and evaluated.

RESULTS

A total of 50 patients, 20 from Group 1 and 30 from Group 2, were included in our study. The mean age was 13.80 ± 3.98 years in Group 1 and 14.67 ± 4.24 years in Group 2, and no statistically significant difference was found between the groups (p > 0.05). While 60% of the patients in Group 1 were male, in Group 2, 53% of the patients were male. Cyst area was recorded as 1171 (512-2310) mm2. The visfatin value was 10.70 ± 5.91 ng/mL in Group 1 and 15.23 ± 5.86 ng/mL in Group 2. The visfatin value in the ABC group was found to be statistically significantly lower than the control group (p < 0.05). No correlation was found between cyst area and visfatin (p > 0.05).

CONCLUSION

Our study found that visfatin levels are significantly lower in patients with ABC s compared to healthy controls, suggesting its potential as a diagnostic biomarker. The ROC analysis showed a good diagnostic ability.