Zeitschrift fur Rheumatologie · 2015
[Childhood vasculitis].
Аннотация на английскомСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Kümmerle-Deschner J B, Thomas J, Benseler S M
Аннотация
BACKGROUND: The primary vasculitides are rare conditions in childhood. The most common disease subtypes are Schönlein-Henoch purpura and Kawasaki's syndrome, which frequently have a self-limiting course. In the majority of vasculitides, the etiology remains unknown. Environmental exposure, including infections, is suspected to trigger an autoinflammatory response in predisposed individuals.
GOAL: The aim of this review is to present the various aspects of childhood vasculitis.
MATERIALS AND METHODS: Reviews and special original papers on childhood vasculitis, published classification criteria and current therapy guidelines were reviewed and summarized.
RESULTS: The classification of vasculitides in childhood has been modified from the previous adult Chapel Hill classification for vasculitides in 2008. Most therapy recommendations for children are adapted from results of studies in adults. This review covers the current classifications, pathogenesis, clinical manifestations and therapy recommendations for children.
DISCUSSION: Although etiology and pathogenesis of many vasculitides in childhood are still unknown, clarifying diagnostic methods and effective therapeutic options are available. The knowledge about various forms of disease manifestation may contribute to an early diagnosis and timely initiation of treatment, which may prevent devastating irreversible impairment.
GOAL: The aim of this review is to present the various aspects of childhood vasculitis.
MATERIALS AND METHODS: Reviews and special original papers on childhood vasculitis, published classification criteria and current therapy guidelines were reviewed and summarized.
RESULTS: The classification of vasculitides in childhood has been modified from the previous adult Chapel Hill classification for vasculitides in 2008. Most therapy recommendations for children are adapted from results of studies in adults. This review covers the current classifications, pathogenesis, clinical manifestations and therapy recommendations for children.
DISCUSSION: Although etiology and pathogenesis of many vasculitides in childhood are still unknown, clarifying diagnostic methods and effective therapeutic options are available. The knowledge about various forms of disease manifestation may contribute to an early diagnosis and timely initiation of treatment, which may prevent devastating irreversible impairment.