Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2008
[Autologous free fat particle grafting combined with bFGF to repair facial depression].
Клинический случайАннотация на английскомСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Han Yanfu, Liu Jun
Аннотация
OBJECTIVE: To evaluate the effect of autologous free fat particle grafting combined with-bFGF to repair facial depression.
METHODS: From April 2004 to May 2006, 41 patients with facial depression were randomized into two groups (groups A and B). In group A, 12 cases were admitted from April 2004 to December 2004. There were 5 males and 7 females, aging 16-49 years (mean, 31 years). The pathological causes were congenital facial depression in 2 patients, hemifacial atrophy in 2, traumatic cicatrix in 5 and benign tumor removal in 3. The course of disease was 2-19 years. The concave regions were low (0.52 +/- 0.13) cm compared to surrounding normal skin, concave area (16.0 +/- 5.3) cm2. In group B, 29 cases were admitted from January 2005 to May 2006. There were 14 males and 15 females, aging 18-52 years (mean, 37 years). The pathological causes were: congenital facial depression in 3 patients, hemifacial atrophy in 4, traumatic cicatrix in 15 and benign tumor removal in 7. The course of disease was 2-20 years. The concave regions were low (0.58 +/- 0.15) cm compared to surrounding normal skin, concave area (18.0 +/- 6.2) cm2. Cases in group A were treated with pure autologous free fat particle injection; cases in group B were treated with autologous free fat particle injection combined with bFGF (4,200 IU/10 mL). The clinical outcome were comparatively analyzed between two groups after operation.
RESULTS: The follow-up time was 6 to 24 months (mean, 12.5 months) in group A and 6 to 24 months (mean, 13 months) in group B. In group A, 6 patients achieved satisfactory clinical effect after one injection of fat particle, the satisfactory rate of one therapy being 50%; other 6 cases were required reinjection of fat particle 6-12 months postoperatively, of which two-time injections in 3 cases, three-time injections in 3 cases. In group B, 24 patients achieved satisfactory clinical effect after one injection of fat particle, the satisfactory rate of one therapy being 82.8%; only 5 cases were required reinjection one year postoperatively. There was statistically significant difference in the satisfactory rate of one injection between two groups (P < 0.05).
CONCLUSION: Autologous free fat particle grafting combined with bFGF to treat facial depression can acquire satisfactory clinical effect, which is a safe and effective method.
METHODS: From April 2004 to May 2006, 41 patients with facial depression were randomized into two groups (groups A and B). In group A, 12 cases were admitted from April 2004 to December 2004. There were 5 males and 7 females, aging 16-49 years (mean, 31 years). The pathological causes were congenital facial depression in 2 patients, hemifacial atrophy in 2, traumatic cicatrix in 5 and benign tumor removal in 3. The course of disease was 2-19 years. The concave regions were low (0.52 +/- 0.13) cm compared to surrounding normal skin, concave area (16.0 +/- 5.3) cm2. In group B, 29 cases were admitted from January 2005 to May 2006. There were 14 males and 15 females, aging 18-52 years (mean, 37 years). The pathological causes were: congenital facial depression in 3 patients, hemifacial atrophy in 4, traumatic cicatrix in 15 and benign tumor removal in 7. The course of disease was 2-20 years. The concave regions were low (0.58 +/- 0.15) cm compared to surrounding normal skin, concave area (18.0 +/- 6.2) cm2. Cases in group A were treated with pure autologous free fat particle injection; cases in group B were treated with autologous free fat particle injection combined with bFGF (4,200 IU/10 mL). The clinical outcome were comparatively analyzed between two groups after operation.
RESULTS: The follow-up time was 6 to 24 months (mean, 12.5 months) in group A and 6 to 24 months (mean, 13 months) in group B. In group A, 6 patients achieved satisfactory clinical effect after one injection of fat particle, the satisfactory rate of one therapy being 50%; other 6 cases were required reinjection of fat particle 6-12 months postoperatively, of which two-time injections in 3 cases, three-time injections in 3 cases. In group B, 24 patients achieved satisfactory clinical effect after one injection of fat particle, the satisfactory rate of one therapy being 82.8%; only 5 cases were required reinjection one year postoperatively. There was statistically significant difference in the satisfactory rate of one injection between two groups (P < 0.05).
CONCLUSION: Autologous free fat particle grafting combined with bFGF to treat facial depression can acquire satisfactory clinical effect, which is a safe and effective method.