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DOI 10.1002/alz.71291

Медицинская библиотека · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026

Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.

Rae Rosaria J, Alberhasky Jessica Marie Hunter, Baillet Marion, Bangasser Debra A, Belloy Michael E, Berry Anne S, Berteotti Chiara, Bow Hannah, Buckley Rachel, Caldwell Jessica Z K, Carpi Matteo, Clark Benjamin J, Ciampa Claire J, Conley Alexander C, Dahl Martin J, Donaldson Zoe R, Ehrenberg Alexander J, Einstein Gillian, Falgàs Neus, Fenlon Haley A, Fitzhugh Megan C, Froemke Robert C, Gallay Clara, Grinberg Lea Tenenholz, Hamilton Derek A, Hasan Zia, Huarte Oihane Uriarte, Jabeen Shaista, Jacobs Heidi I L, Kolling Louis John, Koops Elouise A, Lenzoni Sabrina, Liguori Claudio, Manca Riccardo, Marcinkiewcz Catherine A, Omoluabi Tamunotonye, Oria Rademene, Orsini Caitlin A, Ortega Nancy Elizabeth, Pa Judy, Pentkowski Nathan S, Pereira Joana B, Ramos Rhudovic, Sargin Derya, Satpati Abhijit, Selles Maria Clara, Seto Mabel, Shaik Shabana M, Sindi Shireen, Son Gowoon, Ucheagwu Valentine, Van Egroo Maxime, Yuan Qi, Kelberman Michael A

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Аннотация

Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia-related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex-specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in males and females, while other regions display nominal sex differences. However, the relevance of sex differences in modulating dysfunction of NSSs in Alzheimer's disease (AD) and related dementias is not well understood. This review is a joint effort by the Neuromodulatory Subcortical Systems and Sex and Gender Differences in Alzheimer's Disease Professional Interest Areas of the Alzheimer's Association. We review sex differences in NSSs, both in non-disease states and in AD models and patients. We highlight the possible role of NSSs in driving sex-specific AD susceptibility and potential footholds for sex-based interventions targeting these systems. We conclude by outlining immediate and long-term actions to address the intersection of NSSs, sex, and AD.

Для цитирования: Rae Rosaria J, Alberhasky Jessica Marie Hunter, Baillet Marion, Bangasser Debra A, Belloy Michael E, Berry Anne S, Berteotti Chiara, Bow Hannah, Buckley Rachel, Caldwell Jessica Z K, Carpi Matteo, Clark Benjamin J, Ciampa Claire J, Conley Alexander C, Dahl Martin J, Donaldson Zoe R, Ehrenberg Alexander J, Einstein Gillian, Falgàs Neus, Fenlon Haley A, Fitzhugh Megan C, Froemke Robert C, Gallay Clara, Grinberg Lea Tenenholz, Hamilton Derek A, Hasan Zia, Huarte Oihane Uriarte, Jabeen Shaista, Jacobs Heidi I L, Kolling Louis John, Koops Elouise A, Lenzoni Sabrina, Liguori Claudio, Manca Riccardo, Marcinkiewcz Catherine A, Omoluabi Tamunotonye, Oria Rademene, Orsini Caitlin A, Ortega Nancy Elizabeth, Pa Judy, Pentkowski Nathan S, Pereira Joana B, Ramos Rhudovic, Sargin Derya, Satpati Abhijit, Selles Maria Clara, Seto Mabel, Shaik Shabana M, Sindi Shireen, Son Gowoon, Ucheagwu Valentine, Van Egroo Maxime, Yuan Qi, Kelberman Michael A. Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. DOI: 10.1002/alz.71291.

Предметные рубрики MeSH

Alzheimer DiseaseHumansSex CharacteristicsAnimalsBrainFemaleMale
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