BMC oral health · 2026
Synergistic proanthocyanidin-copper oxygen-generating microneedle enhances anti-inflammatory activity in dental pulp stem cells and macrophage efferocytosis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Miao Yating, Wang Yidan, Yang Yun, Luo ZhiPu, Wang Yakang, Lei Bo, Liu Ruirui
Аннотация
BACKGROUND: Dental pulp inflammation and impaired tissue repair remain critical challenges in endodontic therapy, often exacerbated by hypoxia and dysregulated immune responses.
METHODS: We developed a procyanidin-copper-loaded oxygen-generating microneedle hydrogel (CA-PCC-CAT) releasing active components into deeply infected pulp tissue in a pH-responsive manner to exert potent antioxidative and anti-inflammatory effects.
RESULTS: In vitro experiments demonstrated that the hydrogel effectively protected hDPSCs through its multifunctions, including antibacterial activity, antioxidative stress modulation, anti-inflammatory action, and hypoxia alleviation. Simultaneously, it augmented macrophage efferocytosis by scavenging reactive oxygen species (ROS), thereby facilitating the clearance of apoptotic cells and enhancing tissue repair.
CONCLUSIONS: This study represents a promising strategy for developing multifunctional biomaterials to amplify the anti-inflammatory capacity of hDPSCs and advance the field of pulp preservation and regenerative therapy.
METHODS: We developed a procyanidin-copper-loaded oxygen-generating microneedle hydrogel (CA-PCC-CAT) releasing active components into deeply infected pulp tissue in a pH-responsive manner to exert potent antioxidative and anti-inflammatory effects.
RESULTS: In vitro experiments demonstrated that the hydrogel effectively protected hDPSCs through its multifunctions, including antibacterial activity, antioxidative stress modulation, anti-inflammatory action, and hypoxia alleviation. Simultaneously, it augmented macrophage efferocytosis by scavenging reactive oxygen species (ROS), thereby facilitating the clearance of apoptotic cells and enhancing tissue repair.
CONCLUSIONS: This study represents a promising strategy for developing multifunctional biomaterials to amplify the anti-inflammatory capacity of hDPSCs and advance the field of pulp preservation and regenerative therapy.