Interactive and joint associations of C-reactive protein-triglyceride glucose index and body roundness index on incident cardiovascular diseases: a nationwide prospective cohort study.

BACKGROUND AND AIM: The C-reactive protein-triglyceride glucose index (CTI) and body roundness index (BRI) are novel composite biomarkers reflecting metabolic-inflammatory dysregulation and visceral obesity. However, their associations with incident cardiovascular diseases (CVDs) remain unclear. This study aimed to investigate the individual and joint associations of CTI and BRI on the risk of CVDs.

METHODS AND

RESULTS

We included 235,163 participants from the UK Biobank. The primary outcomes were the occurrence of coronary heart disease (CHD), atrial fibrillation (AF), heart failure (HF), and stroke events. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for CTI and BRI in relation to incident CVDs. Compared with participants with low CTI and low BRI, individuals with both high CTI and high BRI had significantly higher risks of CHD (HR = 1.36), AF (HR = 1.38), HF (HR = 1.90), and stroke (HR = 1.09). Furthermore, statistically significant additive interactive associations between CTI and BRI were observed for CHD and HF.

CONCLUSIONS

Our findings revealed that elevated levels of CTI and BRI robustly associated with an increased risks of incident CHD, AF, HF, and stroke, and the synergistic associations between CTI and BRI were observed on risks of incident CHD and HF.