Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rezaei Elham, Newkirk Marianna M, Li Zhenhong, Gordon John R, Oen Kiem G, Benseler Susanne M, Boire Gilles, Cabral David A, Campillo Sarah, Chédeville Gaëlle, Chetaille Anne-Laure, Dancey Paul, Duffy Ciaran, Duffy Karen Watanabe, Houghton Kristin, Huber Adam M, Jurencak Roman, Lang Bianca, Morishita Kimberly A, Petty Ross E, Ramsey Suzanne E, Roth Johannes, Schneider Rayfel, Scuccimarri Rosie, Spiegel Lynn, Stringer Elizabeth, Tse Shirley M L, Tucker Lori B, Turvey Stuart E, Yeung Rae S M, Rosenberg Alan M, Alan M. Rosenberg for the BBOP Study Group
Аннотация
METHODS: Plasma sLRP1 and 44 inflammation-related biomarkers were measured at enrollment and 6 months later in a cohort of 96 newly diagnosed Canadian patients with nonsystemic JIA. Relationships between sLRP1 levels and indicators of disease activity and biomarker levels were analyzed at both visits.
RESULTS: At enrollment, sLRP1 levels correlated negatively with age and active joint counts. Children showed significantly higher levels of sLRP1 than adolescents (mean ranks: 55.4 and 41.9, respectively; P = 0.02). Participants with 4 or fewer active joints, compared to those with 5 or more active joints, had significantly higher sLRP1 levels (mean ranks: 56.2 and 40.7, respectively; P = 0.006). At enrollment, considering the entire cohort, sLRP1 correlated negatively with the number of active joints (r = -0.235, P = 0.017). In the entire cohort, sLRP1 levels at enrollment and 6 months later correlated with 13 and 6 pro- and antiinflammatory biomarkers, respectively. In JIA categories, sLRP1 correlations with inflammatory markers were significant in rheumatoid factor-negative polyarticular JIA, oligoarticular JIA, enthesitis-related arthritis, and psoriatic arthritis at enrollment. Higher sLRP1 levels at enrollment increased the likelihood of absence of active joints 6 months later.
CONCLUSION: Plasma sLRP1 levels correlate with clinical and biomarker indicators of short-term improvement in JIA disease activity, supporting sLRP1 as an upstream biomarker of potential utility for assessing JIA disease activity and outcome prediction.