[Clinicopathology analysis of mesenchymal chondrosarcoma in soft tissue].

OBJECTIVE

To investigate the clinicopathological and immunohistochemical characteristics of soft tissue mesenchymal chondrosarcoma.

METHODS

The clinical material, pathological and immunohistochemical characteristics (reaction to LCA, CD3, CD20, CD45RO, CD79a, CD99, NSE, S-100, Syn, CgA, CK7, CK19, EMA, Coll-II, Sarcomeric-Actin, Desmin, Ki-67,P53) of 2 cases of soft tissue mesenchymal chondrosarcoma in Jishuitan Hospital between 1995 and 2005 were reviewed and followed up.

RESULTS

The two patients were both females. The tumors were located in the low extremity muscles. The main roentgenographical appearance was stippled calcification in tumor and calcification at the edge of the tumor. The histological characteristic features showed undifferentiated small cells together with islands of chondrosarcoma; there was hemangiopericytoma-like arrangement of small cells. The tumor cells were positive for CD99, NSE, Syn, CgA; The cells in chondroid matrix were positive for S-100; chondroid matrix was positive for Coll-II. All tumor cells were negative for LCA, CD3, CD20, CD45RO, CD79a,Sarcomeric-actin, Desmin and CK7, CK19, and EMA. The patient with followed radiotherapy was alive. and the other without radiotherapy dead.

CONCLUSION

Mesenchymal chondrosarcoma of soft tissue has the characteristics of primary mesenchyme which differentiates to congenital cartilage. The pathological characteristics of bimophic pattern and roentgenographical appearance of tumor are useful for diagnosis. The prognosis is poor.