The Pediatric infectious disease journal · 2020
Pediatric Community-Acquired Bone and Joint Staphylococcus Aureus Infections In Europe: Severe Infections are Associated to Panton-Valentine Leucocidin Presence.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Gijón Manuel, Bellusci Marcello, Petraitiene Birute, Noguera-Julian Antoni, Glikman Daniel, Saavedra-Lozano Jesús, Neth Olaf, Daskalaki Maria, Zilinskaite Virginija, Kaiser-Labusch Petra, Prieto Luis, Rojo Pablo
Аннотация
To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Panton-Valentine leukocidin-positive isolates were 17%, and 6% of the isolates were methicillin-resistant Staphylococcus aureus. Multivariate analysis identified Panton-Valentine leukocidin presence (adjusted odds ratio, 12.6; P = 0.01) as the only factor independently associated with severe outcome, regardless of methicillin resistance.
Предметные рубрики MeSH
AdolescentArthritis, InfectiousBacterial ToxinsBone and BonesChildChild, PreschoolCommunity-Acquired InfectionsEuropeExotoxinsHumansInfantInfant, NewbornJointsLeukocidinsMethicillin-Resistant Staphylococcus aureusProspective StudiesSeverity of Illness IndexStaphylococcal InfectionsStaphylococcus aureusVirulence Factors