Fibrinoid necrosis of liver parenchymal cells.

By means of different histological and histochemical investigations and fluorescence microscopy it has been possible to demonstrate fibrinoid necrosis of parenchymal liver cells in cases of delayed chloroform death and in septic, toxic and infectious hepatitis. This type of necrosis has previously been observed only in connective tissue and in vessel walls, in particular in collagenoses. It was also possible to provoke this type of liver cell necrosis in animal experiments. Reference has been made to differences in the chemical composition of the fibrinoid substance and to relations to other related substances (amyloid, keratin, fibrin). The importance of fluorescence microscopic invesitgations with fluorochromes, using Novelli's method, and with certain other procedures is emphasized.