European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020
E.U. paediatric MOG consortium consensus: Part 3 - Biomarkers of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders.
СтатьяОбзорConsensus StatementНазвание и аннотация: Перевод в очереди
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Armangue Thaís, Capobianco Marco, de Chalus Aliénor, Laetitia Giorgi, Deiva Kumaran, E.U. paediatric MOG consortium
Аннотация
A first episode of acquired demyelinating disorder (ADS) in children is a diagnostic challenge as different diseases can express similar clinical features. Recently, antibodies against myelin oligodendrocyte glycoprotein (MOG) have emerged as a new ADS biomarker, which clearly allow the identification of monophasic and relapsing ADS forms different from MS predominantly in children. Due to the novelty of this antibody there are still challenges and controversies about its pathogenicity and best technique to detect it. In this manuscript we will discuss the recommendations and caveats on MOG antibody assays, role in the pathogenesis, and additionally discuss the usefulness of other potential new biomarkers in MOG-antibody associated disorders (MOGAD).