Medicine · 2025
Brain microhemorrhages in adult-onset Still's disease: A case report.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
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Kim Jung Youn, Choi Hye Jeong, Kim Sang Heum
Аннотация
RATIONALE: Adult-onset Still's disease (AOSD) is a rare, systemic inflammatory disease. Neurological involvement in AOSD has rarely been reported. In this case report, we describe a 44-year-old male patient with AOSD who presented with seizures and scattered microhemorrhages on brain magnetic resonance imaging (MRI). We recommend brain MRI evaluation, including susceptibility-weighted imaging (SWI), for patients with AOSD who exhibit neurological symptoms.
PATIENT CONCERNS: A 44-year-old male patient presented to the clinic for a strikingly high fever, sore throat and myalgia that persisted for 3 weeks. The vital signs were stabilized upon empirical treatment after admission. On the 11th day after admission, he showed high spiking fever (up to 39.9°C) and generalized tonic-colonic seizure for 5 minutes. Extremely elevated serum ferritin level (≥16,500 ng/mL) was noted over the detection limit. Brain MRI with SWI showed multiple tiny dark signals in the splenium of the corpus and the subcortical white matter.
DIAGNOSES: AOSD was diagnosed based on the Yamaguchi criteria.
INTERVENTIONS: Nonsteroidal anti-inflammatory drugs (NSAID), Tacrolimus, Hydroxychloroquine, and anticonvulsants.
OUTCOMES: The patient recovered and the seizures did not recur.
LESSONS: Brain MRI evaluation, including SWI, is essential for patients with AOSD who present with neurological symptoms.
PATIENT CONCERNS: A 44-year-old male patient presented to the clinic for a strikingly high fever, sore throat and myalgia that persisted for 3 weeks. The vital signs were stabilized upon empirical treatment after admission. On the 11th day after admission, he showed high spiking fever (up to 39.9°C) and generalized tonic-colonic seizure for 5 minutes. Extremely elevated serum ferritin level (≥16,500 ng/mL) was noted over the detection limit. Brain MRI with SWI showed multiple tiny dark signals in the splenium of the corpus and the subcortical white matter.
DIAGNOSES: AOSD was diagnosed based on the Yamaguchi criteria.
INTERVENTIONS: Nonsteroidal anti-inflammatory drugs (NSAID), Tacrolimus, Hydroxychloroquine, and anticonvulsants.
OUTCOMES: The patient recovered and the seizures did not recur.
LESSONS: Brain MRI evaluation, including SWI, is essential for patients with AOSD who present with neurological symptoms.