Sprayable Dual-Network Microgel Adhesive for Robust Wet Adhesion and Prolonged Analgesia in Complex Wounds.

Managing deep, irregular wounds remains challenging due to poor suturability, persistent bleeding-induced wet environments, and neuropathic pain. Here, we have developed a sprayable dual-network microgel adhesive (PR) that rapidly covers complex wound geometries, combining strong wet tissue adhesion with sustained ropivacaine release. The sprayable powder format allows PR microgels to penetrate and adhere to irregular wound beds that conventional dressings cannot reach, with uniform particle size ensuring complete wound protection. Notably, PR maintains exceptional wet adhesion (∼40 kPa, over four times stronger than fibrin glue), enabling reliable sealing even under active bleeding conditions where liquid adhesives fail. The spray application simultaneously delivers liposomal ropivacaine, providing sustained analgesia (240 h release) that maintains pain-free mobility for over 168 h post-operation in rodent models. This on-demand sprayable platform addresses key limitations in wound management by integrating instant hemostatic adhesion with prolonged pain relief in a single conformable format, demonstrating significant potential for clinical application.