The Journal of experimental medicine · 2024

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children.

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Bastard Paul, Gervais Adrian, Taniguchi Maki, Saare Liisa, Särekannu Karita, Le Voyer Tom, Philippot Quentin, Rosain Jérémie, Bizien Lucy, Asano Takaki, Garcia-Prat Marina, Parra-Martínez Alba, Migaud Mélanie, Tsumura Miyuki, Conti Francesca, Belot Alexandre, Rivière Jacques G, Morio Tomohiro, Tanaka Junko, Javouhey Etienne, Haerynck Filomeen, Duvlis Sotirija, Ozcelik Tayfun, Keles Sevgi, Tandjaoui-Lambiotte Yacine, Escoda Simon, Husain Maya, Pan-Hammarström Qiang, Hammarström Lennart, Ahlijah Gloria, Abi Haidar Anthony, Soudee Camille, Arseguel Vincent, Abolhassani Hassan, Sahanic Sabina, Tancevski Ivan, Nukui Yoko, Hayakawa Seiichi, Chrousos George P, Michos Athanasios, Tatsi Elizabeth-Barbara, Filippatos Filippos, Rodriguez-Palmero Agusti, Troya Jesus, Tipu Imran, Meyts Isabelle, Roussel Lucie, Ostrowski Sisse Rye, Schidlowski Laire, Prando Carolina, Condino-Neto Antonio, Cheikh Nathalie, Bousfiha Ahmed A, El Bakkouri Jalila, COVID Clinicians, GEN-COVID Study Group, COVID Human Genetic Effort, Peterson Pärt, Pujol Aurora, Lévy Romain, Quartier Pierre, Vinh Donald C, Boisson Bertrand, Béziat Vivien, Zhang Shen-Ying, Borghesi Alessandro, Pession Andrea, Andreakos Evangelos, Marr Nico, Mentis Alexios-Fotios A, Mogensen Trine H, Rodríguez-Gallego Carlos, Soler-Palacin Pere, Colobran Roger, Tillmann Vallo, Neven Bénédicte, Trouillet-Assant Sophie, Brodin Petter, Abel Laurent, Jouanguy Emmanuelle, Zhang Qian, Martinón-Torres Federico, Salas Antonio, Gómez-Carballa Alberto, Gonzalez-Granado Luis I, Kisand Kai, Okada Satoshi, Puel Anne, Cobat Aurélie, Casanova Jean-Laurent

Аннотация

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.

Предметные рубрики MeSH

Child Humans COVID-19 Interferon-alpha Interferon Type I Autoantibodies

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH