The interplay between osteosarcopenia and intrinsic capacity: insights and associations with all-cause mortality in the Toledo Study for Healthy Aging.
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Baltasar-Fernandez Ivan, Valenzuela Pedro L, Rodríguez-Gómez Irene, Quiñonez-Bareiro Fabio, Alegre Luis M, Prokopidis Konstantinos, Rodriguez-Mañas Leocadio, Ara Ignacio, Rosas-Carrasco Oscar, Williams Lana J, Ramirez-Vélez Robinson, Pasco Julie A, Hajj-Boutros Guy, Agnihotram Raman, Sim Marc, Lok Ok Choo Wayne, Imani Mahdi, Ayala-Copete Ana M, Chabot Julia, Borda Miguel G, Neto Nailton J, Godard-Sebillotte Claire, Bergman Howard, Andrianova Anna, Arai Hidenori, Gaudreau Pierrette, Chen Liang Kung, Samhat Hussein, Alexandre Tiago D S, Guerra Ricardo, Faust Andréa, Papaioannou Alexandra, Sekhon Harmehr, Connolly Emma, Duque Gustavo, García-García Francisco J, Transforming Health and Resilience for Healthy Lives (THRIVE) Project Group
Аннотация
METHODS: We conducted a cross-sectional analysis of IC and a prospective analysis of all-cause mortality in 1142 participants from the Toledo Study for Healthy Aging (75.1 ± 6.0 years, 53.1% women). Participants were classified as having no musculoskeletal disorders, osteopenia/osteoporosis, sarcopenia, or osteosarcopenia (DXA- and EWGSOP2-based criteria). IC was operationalized as a composite score integrating locomotion, cognition, psychological, vitality, and sensory domains.
RESULTS: Older adults with osteosarcopenia exhibited lower total IC (76.6 ± 1.1 points) than those without musculoskeletal disorders (83.7 ± 0.5 points; p < .001) or with osteopenia/osteoporosis (81.3 ± 0.3 points; p < .001), with significant differences also found between the latter groups (p < .001). Specifically, osteosarcopenia was associated with poorer results in the locomotion, cognition, vitality, and sensory domains (all p < .01), but not in the psychological domain. Over a median 6.2-year follow-up, osteosarcopenia-but not osteopenia/osteoporosis-was associated with a higher risk of mortality compared to those without musculoskeletal disorders [HR (95% CI)=1.96 (1.02-3.77); p = .045]. In joint analyses with IC status (high vs low, segregated by the median), this association was specifically observed among participants with osteosarcopenia and low IC [HR = 2.55 (1.31-4.96); p = .004].
CONCLUSIONS: Osteosarcopenia is associated with lower total IC and impairments across most IC domains. This finding is of clinical relevance, as the combination of this condition and low IC is associated with an increased mortality risk.