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Nature medicine · 2026

The exposome of brain aging across 34 countries.

СтатьяНазвание и аннотация: Перевод в очереди
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Legaz Agustina, Moguilner Sebastian, Barttfeld Pablo, Cuadros Castro Jhosmary, Galván Rial Dante Sebastián, Migeot Joaquin, Farina Francesca R, Gonzalez-Gomez Raul, Salazar-Londoño Salomón, de Souza Azzi Tiago, Alcauter Sarael, Amoruso Lucia, Anghinah Renato, Bakr May, Behrens María Isabel, Bruno Martin A, Cardona Juan Felipe, Chen Christopher, Colliot Olivier, Custodio Nilton, d'Acremont Quentin, Debette Stéphanie, Dzianok Patrycja, Güntekin Bahar, Huguet Jordi, Jarne Cecilia, Joliot Marc, Karageorgiou Elissaios, Khedr Eman M, Koopowitz Sheri-Michelle, Kublik Ewa, Lee Jinkook, Aksman Leon, Lopez Susanna, Margaretic Paula, Matallana Diana, Matis Sophie, Miltiadous Andreas, Novotni Gabriela, Orio Patricio, Parra Mario A, Reppermund Simone, de Paula França Resende Elisa, Salum Giovanni Abrahão, Slachevsky Andrea, Ortiz Ana Luisa Sosa, Takada Leonel Tadao, Toh An Qi, Tzallas Alexandros, Wen Wei, Whelan Robert, Yener Görsev, Zegarra Valdivia Jonathan Adrián, Alexoudi Athanasia, Arshad Faheem, Atta Haisam, Avila-Funes Jose Alberto, Santos Jasmin Bonilla, Bruña Ricardo, Castelblanco-Toro Sandra Milena, Chino Vilca Brenda Nadia, Coronel-Oliveros Carlos, Crivello Fabrice, Cruzat Josephine, Dellavale Damián, Dhooge Catherina, Di Caterina Gaetano, Escudero Javier, Esquivias Farias Juan Manuel, Eze Laz Ude, Evans Tavia E, Farombi Temitope, Fernández Alberto, Fittipaldi Sol, Portillo Florencia, Martinic Gonzalo Forno, García Adolfo M, Garcia-Cordero Indira, Gaurav Rahul, Godoy Maria Eugenia, Gonzalez Campo Cecilia, González Hernández Alfredis, Hanoğlu Lütfü, Hazelton Jessica L, Herzog Rubén, Ikiz Burcin, Njamnshi Alfred Kongnyu, Landin-Romero Ramon, López María Eugenia, Maito Marcelo Adrián, Medel Vicente, Sepúlveda Juan Pablo Morales, Ochoa Gómez John Fredy, Ogbuagu Chukwuanugo, de Oliveira Maira Okada, Ozansoy Mehmet, Palma-Espinosa Javier, Hilal Saima, Zhou Juan Helen, Escudero Stefanie Danielle Piña, Pitman Julie Kay, Prado Pavel, Ramírez González Diego, Reyes Pablo, Santamaría García Hernando, Schröder Johannes, Sitt Jacobo Diego, Soliman Radwa Kamel, Soto-Añari Marcio, Thanissery Nithin, Ito Lucas Toshio, Tsuchida Ami, Tzourio Christophe, Yırıkoğulları Harun, Yokoyama Jennifer S, Aguillon David, Miller Bruce, Alladi Suvarna, Jiang Yang, Navarro Arcadi, Babiloni Claudio, Huepe Artigas David, Piguet Olivier, Sosa Pedro Antonio Valdes, Mostert Cyprian M, Tahmasian Masoud, Li Peng, Hu Kun, Genon Sarah, Stein Dan J, Maestú Fernando, Pievani Michela, Salama Mohamed, Brodaty Henry, Sachdev Perminder S, Lawlor Brian, Eyre Harris A, Miranda J Jaime, Baez Sandra, Tagliazucchi Enzo, Duran-Aniotz Claudia, Hernandez Hernan, Ibanez Agustin

Аннотация

The physical and social exposome affects human aging, and brain clocks may track its effects. However, most studies neglect multidomain exposures (physical, social and political) across diverse settings globally and their associations with brain aging. In this study, we characterized the associations between 73 country-level physical and social exposomal factors and multimodal brain age in 18,701 participants from 34 countries (healthy individuals and those with Alzheimer's disease, frontotemporal lobar degeneration or mild cognitive impairment). Exposome effects were assessed using generalized additive models and meta-analytic frameworks. Aggregated exposome models explained up to 15.5-fold more variance than individual exposures (delta Akaike information criterion (ΔAIC): 2,034-3,127). Physical exposome was primarily associated with accelerated structural brain aging (limbic, subcortical and cerebellar regions), whereas social exposome was more strongly associated with functional brain aging (frontotemporal and limbic networks). Exposome burden accounted for 3.3-9.1-fold higher risk of accelerated aging, exceeding effects of clinical diagnoses. Findings were out-of-sample validated in cross-sectional and longitudinal designs, remained consistent across clinical subgroups and persisted after adjustment for demographics, age correction bias, cognition, scanner type and data quality. The exposome accelerates brain aging in health and disease, underscoring the need to address physical, social and political inequities.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты