The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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South Andrew M, Giammattei Victoria C, Bagley Kiri W, Bakhoum Christine Y, Beasley William H, Bily Morgan B, Biswas Shupti, Bridges Aaron M, Byfield Rushelle L, Campbell Jessica Fallon, Chanchlani Rahul, Chen Ashton, D'Agostino McGowan Lucy, Downs Stephen M, Fergeson Gina M, Greenberg Jason H, Hill-Horowitz Taylor A, Jensen Elizabeth T, Kallash Mahmoud, Kamel Margret, Kiessling Stefan G, Kline David M, Laisure John R, Liu Gang, Londeree Jackson, Lucas Caroline B, Mannemuddhu Sai Sudha, Mao Kuo-Rei, Misurac Jason M, Murphy Margaret O, Nugent James T, Onugha Elizabeth A, Pudupakkam Ashna, Redmond Kathy M, Riar Sandeep, Sethna Christine B, Siddiqui Sahar, Thumann Ashley L, Uss Stephen R, Vincent Carol L, Viviano Irina V, Walsh Michael J, White Blanche D, Woroniecki Robert P, Wu Michael, Yamaguchi Ikuyo, Yun Emily, Weaver Donald J
Аннотация
Despite increasing prevalence of hypertension in youth and high adult cardiovascular mortality rates, the long-term consequences of youth-onset hypertension remain unknown. This is due to limitations of prior research, such as small sample sizes, reliance on manual record review, and limited analytic methods, that did not address major biases. The Study of the Epidemiology of Pediatric Hypertension (SUPERHERO) is a multisite, retrospective registry of youth evaluated by subspecialists for hypertension disorders. Sites obtain harmonized electronic health record data using standardized biomedical informatics scripts validated with randomized manual record review. Inclusion criteria are index visit for International Classification of Diseases, 10th Revision (ICD-10) code-defined hypertension disorder on or after January 1, 2015, and age < 19 years. We exclude patients with ICD-10 code-defined pregnancy, kidney failure on dialysis, or kidney transplantation. Data include demographics, anthropomorphics, US Census Bureau tract, histories, blood pressure, ICD-10 codes, medications, laboratory and imaging results, and ambulatory blood pressure. SUPERHERO leverages expertise in epidemiology, statistics, clinical care, and biomedical informatics to create the largest and most diverse registry of youth with newly diagnosed hypertension disorders. SUPERHERO's goals are to reduce CVD burden across the life course and establish gold-standard biomedical informatics methods for youth with hypertension disorders.