Autoimmunity reviews · 2025
Cochlear T cells and their role in health and disease: A systematic review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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De Backer Evi, Verdoodt Dorien, Ponsaerts Peter, Pasciuto Emanuela, Van Rompaey Vincent
Аннотация
BACKGROUND: The role of T cells in health and disease has already been studied extensively in many organs, yet their activity in the cochlea and involvement in hearing loss remains less explored. This review aims to summarize current existing literature on the presence and activity of T cells in the cochlea and the link between T-cell activity and the development of hearing loss.
METHODS: A systematic review of the literature was performed on PubMed and Web of Science on the 4th of December 2024 using the following search term: ("T-cell" OR "T cells" OR "T-lymphocyte*") AND ("cochlea*" OR "spiral ligament" OR "spiral limbus").
RESULTS: The literature search revealed 20 studies that explored the presence and activity of T cells in the cochlea, as well as associations between T cells and hearing loss. The presence of cochlear T cells was compared between steady-state conditions and stimulated environments, which suggested an increase in cochlear T cells post-stimulation. Additionally, the role of T cells in hearing loss, both causal as protective, are described in 12 studies. Finally, three studies introduce cochlin as an inner ear-specific antigen triggering autoimmunity.
CONCLUSION: This review highlights the critical role of the immune balance in maintaining cochlear homeostasis. Both protective and detrimental T-cell functions have been linked to hearing, reflecting the dual role of T cells in cochlear health. Future therapies for hearing loss should aim to restore the immune balance to support normal hearing functions.
METHODS: A systematic review of the literature was performed on PubMed and Web of Science on the 4th of December 2024 using the following search term: ("T-cell" OR "T cells" OR "T-lymphocyte*") AND ("cochlea*" OR "spiral ligament" OR "spiral limbus").
RESULTS: The literature search revealed 20 studies that explored the presence and activity of T cells in the cochlea, as well as associations between T cells and hearing loss. The presence of cochlear T cells was compared between steady-state conditions and stimulated environments, which suggested an increase in cochlear T cells post-stimulation. Additionally, the role of T cells in hearing loss, both causal as protective, are described in 12 studies. Finally, three studies introduce cochlin as an inner ear-specific antigen triggering autoimmunity.
CONCLUSION: This review highlights the critical role of the immune balance in maintaining cochlear homeostasis. Both protective and detrimental T-cell functions have been linked to hearing, reflecting the dual role of T cells in cochlear health. Future therapies for hearing loss should aim to restore the immune balance to support normal hearing functions.