[Effect of genetic polymorphism of MTNR1A gene on adolescent idiopathic scoliosis].

OBJECTIVE

To investigate whether the MTNR1A gene promotor polymorphism (rs2119882) are associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).

METHODS

226 AIS patients and 277 normal controls were recruited. The maximum Cobb angles were recorded in AIS patients. PCR-RFLP was used for the genotyping.

RESULTS

The genotype and allele frequency distribution were comparable between AIS and normal control, the mean maximum Cobb angle of different genotypes of rs2119882 were similar with each other among AIS patients.

CONCLUSION

The MTNR1A gene promoter polymorphism was neither associated with the occurrence nor the curve severity of AIS.