Медицинская библиотека · The Journal of rheumatology · 2001

Treatment of calcinosis in juvenile dermatomyositis with probenecid: the role of phosphorus metabolism in the development of calcifications.

Harel L, Harel G, Korenreich L, Straussberg R, Amir J

Клинический случайСтатьяПеревод в очереди

Аннотация

OBJECTIVE

To report the efficacy of probenecid for calcinosis of juvenile dermatomyositis (JDM) and assess the changes in phosphorus metabolism during treatment.

METHODS

Biochemical studies of calcium and phosphorus metabolism were performed in a 9-year-old girl with JDM and extensive calcifications before and during probenecid treatment.

RESULTS

The calcifications resolved over 18 months of treatment. Probenecid was found to be effective in reducing calcifications by increasing renal phosphate clearance.

CONCLUSIONS

The tendency for calcifications in some patients with JDM might be related to an increase in renal phosphate reclamation, and therefore, probenecid treatment may be effective in these patients.

Для цитирования: Harel L, Harel G, Korenreich L, Straussberg R, Amir J. Treatment of calcinosis in juvenile dermatomyositis with probenecid: the role of phosphorus metabolism in the development of calcifications.. The Journal of rheumatology. 2001.

Предметные рубрики MeSH

Calcinosis Calcium Child Dermatomyositis Female Humans Phosphorus Probenecid Radiography Uricosuric Agents

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