Scaphoid Reconstruction Following Nonunion in Osteogenesis Imperfecta: A Case Report.

CASE: An 11-year-old boy with osteogenesis imperfecta (OI) type 1 presented with a chronic scaphoid waist nonunion accompanied by cyst formation and dorsal intercalated segment instability. He had a history of treatment with bisphosphonate therapy and discontinued zoledronate 3 months before surgery. He underwent scaphoid reconstruction using nonvascularized, corticocancellous bone graft from the iliac crest and a buried headless compression screw. Within 12 weeks, imaging demonstrated union with bony remodeling and he resumed zoledronate.

CONCLUSION

Temporary discontinuation of bisphosphonate therapy may normalize bone healing and reduce the risk of bisphosphonate-related delayed union in scaphoid reconstruction for children with OI.