Abnormal chaperone-mediated autophagy (CMA) in cardiomyocytes of a boy with Danon disease.

Spine surgery is a highly skill-dependent specialty, where the surgeon's expertise plays a critical role in determining patient outcomes. Despite the traditional emphasis on randomized controlled trials and meta-analyses as the gold standard for clinical research, these methodologies may fall short in accounting for the variability in surgeon proficiency, which significantly influences success rates in spine surgery. This perspective article examines the limitations of relying solely on randomized controlled trials and meta-analyses in skill-driven fields such as spine surgery and argues for a broader research paradigm that incorporates the role of surgical skill and experience. Alternative methodologies, such as observational studies, surgeon-led outcome tracking, and surgical registries, are proposed to better capture the real-world complexities of spine surgery. This perspective article emphasizes the importance of structured training programs, continuous professional development, and proficiency-based education models in improving surgical outcomes. A call to action is made for policymakers, professional organizations, and academic institutions to shift the focus of spine surgery research toward integrating surgeon expertise alongside traditional evidence-based approaches, ultimately fostering innovation and improving patient care.