Haemopathological changes in recurrent deep venous thrombosis of the extremities.

We observed 42 (11.7%) patients with multiple or recurrent thrombosis in 358 patients with deep venous thrombosis of the extremities (DVT) and its sequelae. In those patients with recurrent DVT, following characteristics were found in comparison with patients with recurrent DVT, following characteristics were found in comparison with patients who experienced only one episode of DVT. Collagen disease including Behçet disease are often observed as an important predisposing factor. Relatively high incidence in the young generation. Pulmonary embolism occurred about 4 times as frequent as in patients with single episode of DVT. The platelet adhesiveness increased in 7 (38.9%) cases and the hyperaggregability was also frequently found (34.8% by ADP, 26.1% by collagen), though no significant differences was noted from patients with single episode of DVT. Meanwhile, beta-thromboglobulin increased an antithrombin III decreased with a significant difference. DVT with those characteristics should more carefully be managed.