La Clinica terapeutica · 2026
The Dossanov Intramedullary Telescopic System in the Treatment of Bone Deformities in Children with Osteogenesis Imperfecta. Real-world evidence studies.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Dossanov Bolatbek, Khassenkyzy Altyngul, Dossanova Assem, Anticevic Darko, Batpen Arman
Аннотация
OBJECTIVES: The study aims to evaluate the effectiveness of the Dossanov telescopic implant in the surgical treatment of children with osteogenesis imperfecta (OI).
MATERIALS AND METHODS: A real-world evidence (RWE) retrospective and prospective analysis of the surgical treatment of children with type I, III, and IV OI was performed. Group 1 included 10 patients with OI who had a Dossanov telescopic implant installed (prospective analysis). Group 2 included 12 patients with OI who had a Fassier-Duval telescopic rod installed (retrospective analysis). The average period of postoperative dynamic follow-up was 18-24 months. The average time of bone regeneration for Group 1 was 28.13 ± 1.59 days, while in Group 2, it was 31.47±3.2 days (p = 0.0012).
RESULTS: The early rehabilitation period was 1.62±1.69 months in Group 1 and 1.97±1.66 months in Group 2 (p < 0.001). The average length of bone growth was 11.87±3.41 mm in Group 1 and 23.87±5.8 mm in Group 2 (p = 0.0002). During the observation period, participants in neither group had complications. In Group 1, after 6 months, bone growth elongation was noted by 5.3±0.7 mm. In Group 2, the elongation was 5.7±0.6 mm (p=0.05). In the period of 6-12 months, the elongation results reached 4.8±2.5 mm in Group 1 and 6.4±1.12 mm in Group 2 (p=0.04).
CONCLUSIONS: The Dossanov telescopic system is a modern, reliable, and affordable tool, making it a valuable option for correcting deformities in children with OI.
MATERIALS AND METHODS: A real-world evidence (RWE) retrospective and prospective analysis of the surgical treatment of children with type I, III, and IV OI was performed. Group 1 included 10 patients with OI who had a Dossanov telescopic implant installed (prospective analysis). Group 2 included 12 patients with OI who had a Fassier-Duval telescopic rod installed (retrospective analysis). The average period of postoperative dynamic follow-up was 18-24 months. The average time of bone regeneration for Group 1 was 28.13 ± 1.59 days, while in Group 2, it was 31.47±3.2 days (p = 0.0012).
RESULTS: The early rehabilitation period was 1.62±1.69 months in Group 1 and 1.97±1.66 months in Group 2 (p < 0.001). The average length of bone growth was 11.87±3.41 mm in Group 1 and 23.87±5.8 mm in Group 2 (p = 0.0002). During the observation period, participants in neither group had complications. In Group 1, after 6 months, bone growth elongation was noted by 5.3±0.7 mm. In Group 2, the elongation was 5.7±0.6 mm (p=0.05). In the period of 6-12 months, the elongation results reached 4.8±2.5 mm in Group 1 and 6.4±1.12 mm in Group 2 (p=0.04).
CONCLUSIONS: The Dossanov telescopic system is a modern, reliable, and affordable tool, making it a valuable option for correcting deformities in children with OI.