Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti · 2026
Neuroprotective Properties of Citicoline in Patients with Unexplained Visual Acuity Loss Related to Silicone Oil Tamponade. Our Experience.
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Fellner Zlatica, Kurilová Veronika, Takáčová Adriana, Herdová Lucia, Kolář Petr, Majtánová Nora
Аннотация
AIMS: To review the findings in the professional literature on unexplained loss of visual acuity (VA) in patients with silicone oil (SO) tamponade and post-removal, and assess the efficacy and safety of citicoline as a neuroprotective agent on anatomical changes and visual function in patients undergoing 25-gauge pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment with large/multiple tears (macula-on/off).
MATERIALS AND METHODS: We studied 96 eyes, 64 receiving citicoline (5 ml orally 3x daily) after PPV with SO tamponade, performed from 01.01.2023 to 30.06.2023 at the Eye Clinic of SZU and UNB. Best corrected visual acuity (BCVA) was measured using ETDRS charts, and changes in the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) were assessed using OCT at 1, 3 and 6 months. Complications were monitored and results analyzed statistically.
RESULTS: BCVA improved (citicoline: 19 to 48 letters; non-citicoline: 13 to 42 letters, p.
MATERIALS AND METHODS: We studied 96 eyes, 64 receiving citicoline (5 ml orally 3x daily) after PPV with SO tamponade, performed from 01.01.2023 to 30.06.2023 at the Eye Clinic of SZU and UNB. Best corrected visual acuity (BCVA) was measured using ETDRS charts, and changes in the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) were assessed using OCT at 1, 3 and 6 months. Complications were monitored and results analyzed statistically.
RESULTS: BCVA improved (citicoline: 19 to 48 letters; non-citicoline: 13 to 42 letters, p.