Sleep · 2015
Sleep disorders and increased risk of autoimmune diseases in individuals without sleep apnea.
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Hsiao Yi-Han, Chen Yung-Tai, Tseng Ching-Min, Wu Li-An, Lin Wei-Chen, Su Vincent Yi-Fong, Perng Diahn-Warng, Chang Shi-Chuan, Chen Yuh-Min, Chen Tzeng-Ji, Lee Yu-Chin, Chou Kun-Ta
Аннотация
STUDY OBJECTIVES: To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases.
DESIGN: Cohort study.
SETTING: Nationwide database research.
PARTICIPANTS: 84,996 adult patients with NSD diagnoses recorded in the Taiwan National Health Insurance Research Database between 2000 and 2003, after excluding those with antecedent autoimmune diseases. A comparison cohort of 84,996 participants was formed by age-, gender-, income-, and urbanization-matched controls.
INTERVENTIONS: None.
MEASUREMENTS AND RESULTS: The two cohorts were followed up for occurrence of autoimmune diseases, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and systemic sclerosis (SSc). A Cox proportional hazards regression model was used for muti-variate adjustment. In patients with NSD, the overall risk for incident autoimmune diseases was significantly higher than in controls (adjusted hazard ratio [HR] = 1.47, 95% confidence interval [CI] = 1.41-1.53). With regard to individual diseases, the risks for SLE, RA, AS and SS among NSD patients were also significantly higher than in controls (HR [95% CI] for SLE, RA, AS, and SS were 1.81 [1.50-2.18], 1.45 [1.36-1.54], 1.53 [1.38-1.70], and 1.51 [1.43-1.60], respectively), whereas the increased risk for SSc did not reach statistical significance (HR: 1.36 [0.82-2.26]).
CONCLUSION: Patients with non-apnea sleep disorder were associated with a higher risk for developing autoimmune diseases.
DESIGN: Cohort study.
SETTING: Nationwide database research.
PARTICIPANTS: 84,996 adult patients with NSD diagnoses recorded in the Taiwan National Health Insurance Research Database between 2000 and 2003, after excluding those with antecedent autoimmune diseases. A comparison cohort of 84,996 participants was formed by age-, gender-, income-, and urbanization-matched controls.
INTERVENTIONS: None.
MEASUREMENTS AND RESULTS: The two cohorts were followed up for occurrence of autoimmune diseases, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and systemic sclerosis (SSc). A Cox proportional hazards regression model was used for muti-variate adjustment. In patients with NSD, the overall risk for incident autoimmune diseases was significantly higher than in controls (adjusted hazard ratio [HR] = 1.47, 95% confidence interval [CI] = 1.41-1.53). With regard to individual diseases, the risks for SLE, RA, AS and SS among NSD patients were also significantly higher than in controls (HR [95% CI] for SLE, RA, AS, and SS were 1.81 [1.50-2.18], 1.45 [1.36-1.54], 1.53 [1.38-1.70], and 1.51 [1.43-1.60], respectively), whereas the increased risk for SSc did not reach statistical significance (HR: 1.36 [0.82-2.26]).
CONCLUSION: Patients with non-apnea sleep disorder were associated with a higher risk for developing autoimmune diseases.
Предметные рубрики MeSH
Arthritis, RheumatoidAutoimmune DiseasesCohort StudiesComorbidityFemaleHumansIncidenceIncomeLupus Erythematosus, SystemicMaleMiddle AgedProportional Hazards ModelsRisk FactorsScleroderma, SystemicSjogren's SyndromeSleep Apnea SyndromesSleep Wake DisordersSpondylitis, AnkylosingTaiwanUrban Population