Seroepidemiological survey of rubella immunity among three populations in Shiraz, Islamic Republic of Iran.

We used indirect ELISA assay to test 1193 sera for rubella IgG and IgM antibodies in a seroepidemiological survey of three age- and gender-differentiated sample populations in Shiraz: 203 children aged 2-7 years, 255 paired mothers and neonates (cord blood) and 480 women aged 14-70 years. Seropositivity among women aged 14-70 years was 96.2%. No IgM positive case was found among the 255 tested cord blood samples. Seropositivity among the 203 children was 97.0% (much higher than previously reported). This may be due to rubella epidemics, which tend to occur every 6-10 years. The impact of introducing rubella vaccination is discussed.