Перивноградиентные градиенты в микроструктуре аксона и миелина присутствуют у людей с множественным склерозом с низкой и высокой степенью инвалидности.
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Bernstein Hannah R, Grouza Vladimir, Gati Joseph S, Morrow Sarah A, Menon Ravi S, Narayanan Sridar, Arnold Douglas L, Rudko David A
Аннотация
Оригинал публикации
Periventricular gradients in axonal and myelin microstructure are present in people with multiple sclerosis having low and high disability.
BACKGROUND: MS imaging studies have demonstrated an ependymal "surface-in" distribution of white matter damage. The origin of this effect and how it impacts myelinated axons in people with MS (PwMS) is poorly understood.
OBJECTIVES: To investigate (1) whether there is clear evidence of tract-wise, periventricular damage, based on fractional anisotropy, mean diffusivity, axonal water fraction (AWF) and myelin volume fraction (MVF), in PwMS, (2) if such tissue damage is associated with T1-"black-hole" (T1-BH) and/or non-BH lesions, and (3) if periventricular quantitative MRI abnormalities are correlated with lateral ventricle (LV) and choroid plexus (CP) enlargement.
METHODS: We applied structural, MT-weighted, and multi-shell diffusion MRI in healthy controls and PwMS to quantify periventricular gradient damage to axons and myelin. We also evaluated the correlation between such gradient damage and both non-BH and T1-BH lesion loads, and brain volume changes.
RESULTS: Clear periventricular gradients exist in both AWF and MVF measures in the Association and Projection Tracts. They are strongly correlated with T1-BH lesion load, and with LV and CP enlargement in PwMS with EDSS > 2.
CONCLUSIONS: Tract-specific, periventricular gradients in PwMS exist prominently in AWF and MVF, are strongly associated with T1-BH lesion loads, and correlate with LV and CP enlargement.