International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Time to sputum culture conversion and its predictors among drug-resistant tuberculosis patients in Ethiopia: a systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Eshetu Daniel Mulat, Yewodiaw Thomas Kidanemariam, Shitu Birhanu Feleke, Delie Amare Mebrat, Abneh Aysheshim Asnake, Alemayehu Asnakew Demissie, Gelaw Sintayehu Shiferaw, Kassahun Mulatu, Endayehu Mequannt Alemu, Haimanot Aysheshim Belaineh, Mulugeta Adugna Mengesha, Ambaw Yihenew Getahun, Bitewa Mequanent Dessie, Wondie Smegnew Gichew, Kassie Tadele Derbew, Mengie Zinie Abita, Tafere Berhanu Ayana, Mekonnen Tesfaye Shumet, Molla Mikias Getahun
Аннотация
BACKGROUND: Drug-resistant tuberculosis remains a major public health challenge in Ethiopia. Delayed sputum culture conversion prolongs infectiousness and worsens treatment outcomes, yet evidence on its timing and predictors is inconsistent.
OBJECTIVE: To estimate the pooled time to sputum culture conversion and identify its predictors among drug-resistant tuberculosis patients in Ethiopia.
METHODS: A systematic search of PubMed, Google Scholar, Embase, Scopus, Web of Science, and Ethiopian university repositories was conducted for studies published between January 2000 and March 2026. Data were analyzed using R (version 4.4.2) and Stata/MP 17. Heterogeneity and publication bias were assessed. Subgroup analyses and sensitivity analysis explored sources of variation.
RESULTS: Eleven retrospective cohort studies with 2851 patients were included. The pooled median time to sputum culture conversion was 68.92 days (IQR: 57.64-80.19; I² = 99.87%). Delayed conversion was associated with previous anti-tuberculosis treatment (aHR = 0.46; 95% CI: 0.33-0.64), smear grades (+2: aHR = 0.42; 95% CI: 0.26-0.68, and +3: aHR = 0.42; 95% CI: 0.29-0.61), underweight status (aHR = 0.75; 95% CI: 0.65-0.84), and lung cavitation (aHR = 0.48; 95% CI: 0.33-0.69).
CONCLUSION: Culture conversion occurs at approximately two months. Identified risk factors highlight the need for early risk stratification, nutritional support, and close monitoring to improve outcomes.
PROSPERO REGISTRATION NUMBER: CRD420261348090.
OBJECTIVE: To estimate the pooled time to sputum culture conversion and identify its predictors among drug-resistant tuberculosis patients in Ethiopia.
METHODS: A systematic search of PubMed, Google Scholar, Embase, Scopus, Web of Science, and Ethiopian university repositories was conducted for studies published between January 2000 and March 2026. Data were analyzed using R (version 4.4.2) and Stata/MP 17. Heterogeneity and publication bias were assessed. Subgroup analyses and sensitivity analysis explored sources of variation.
RESULTS: Eleven retrospective cohort studies with 2851 patients were included. The pooled median time to sputum culture conversion was 68.92 days (IQR: 57.64-80.19; I² = 99.87%). Delayed conversion was associated with previous anti-tuberculosis treatment (aHR = 0.46; 95% CI: 0.33-0.64), smear grades (+2: aHR = 0.42; 95% CI: 0.26-0.68, and +3: aHR = 0.42; 95% CI: 0.29-0.61), underweight status (aHR = 0.75; 95% CI: 0.65-0.84), and lung cavitation (aHR = 0.48; 95% CI: 0.33-0.69).
CONCLUSION: Culture conversion occurs at approximately two months. Identified risk factors highlight the need for early risk stratification, nutritional support, and close monitoring to improve outcomes.
PROSPERO REGISTRATION NUMBER: CRD420261348090.