Haematologica · 1991
Modulation of allogeneic cytotoxic activity by factor VIII or IX concentrates.
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Soria A G, Bouzas M B, Anselmo A, Ruibal-Ares B H
Аннотация
BACKGROUND AND METHODS: The ability of peripheral blood mononuclear cells (PBMC) to generate cytotoxic T lymphocytes (CTL) that react against alloantigens was evaluated in hemophilic patients (He) with or without human immunodeficiency virus (HIV) infection.
RESULTS AND CONCLUSIONS: We demonstrated that PBMC from HIV seronegative and seropositive He had a decreased response when compared to normal controls. The decreased CTL response to alloantigens may be due to the immunosuppressive effects of factor VIII or IX concentrates, as well as to the different pathway of HIV infection when compared to other acquired immunodeficiency syndrome risk groups.
RESULTS AND CONCLUSIONS: We demonstrated that PBMC from HIV seronegative and seropositive He had a decreased response when compared to normal controls. The decreased CTL response to alloantigens may be due to the immunosuppressive effects of factor VIII or IX concentrates, as well as to the different pathway of HIV infection when compared to other acquired immunodeficiency syndrome risk groups.