[Pathology of the synapses of the central nervous system].

Combined electron-microscopic and autoradiographic examination of axosomatic and axodendritic synapses in the central nervous system after various extreme exposures (phenamin, alcohol intoxication, local tetanus, shock, radiation trauma) was made. Destructive changes of the synapses and dendritic spines manifested in dissociation of pre- and postsynaptic parts, disorganization of the spine apparatus. Autoradiography revealed a various degree of the exogenous labelled mediator incorporation.