The Indian journal of tuberculosis · 2025
Survival analysis for TB and TB-associated HIV children seek medical care at the infectious department, Tripoli University Hospital: Retrospective cohort.
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Dakheel Hajir Ali, Dakheel Monira Ali, Abdulsalam Rashed Najiah
Аннотация
INTRODUCTION: Tuberculosis (TB) is caused by Mycobacterium tuberculosis and mostly affects the lungs, making pulmonary illness a frequent TB presentation, Due to the presence of migrants from various nations, TB is one of the main causes of mortality in Libya. In 2021, the incidence of TB in the country reached 59 per 100,000 per year, and TB-related deaths were 13 per 100,000 per year.
AIM: This study aims to understand factors related to the survival of patients with TB, and TB-associated HIV patients.
METHODOLOGY: a retrospective cohort and data were collected between June 2016 and June 2021 from Tripoli University Hospital Data was analyzed by (SPSS) descriptive analysis for different variables, and relative risk in addition to hazard risk was estimated by Cox regression at 95% confidence interval, and Kaplan-miere for survival significant by log-rank, at p-value 0.05.
RESULT: (49.1%) males and, (50.9%) females. 76.4% of them were age group 5-15 years. 62.0% of cases were lives in Tripoli. The 33.4% of cases were diagnosed clinically. hazard ratio, cox regression shows HR13.065 for HIV state at p = 0.000 with CI (4.144-41.191), hospitalization shows HR 16.777 at p = 0.000 at CI (3.676-76.573). Survival analysis was significant by log-rank to Anti-TB started after 90 days of ART initiation HR 10.025 at p = 0.004 at CI (2.082-48.275), and hospitalization at p = 0.01 hospitalization was significantly associated with HIV infection by Fisher exact test p = 0.000.
CONCLUSION: HIV state and time of ATT initiation major cause of death in TB pediatric cases in Tripoli University Hospital.
AIM: This study aims to understand factors related to the survival of patients with TB, and TB-associated HIV patients.
METHODOLOGY: a retrospective cohort and data were collected between June 2016 and June 2021 from Tripoli University Hospital Data was analyzed by (SPSS) descriptive analysis for different variables, and relative risk in addition to hazard risk was estimated by Cox regression at 95% confidence interval, and Kaplan-miere for survival significant by log-rank, at p-value 0.05.
RESULT: (49.1%) males and, (50.9%) females. 76.4% of them were age group 5-15 years. 62.0% of cases were lives in Tripoli. The 33.4% of cases were diagnosed clinically. hazard ratio, cox regression shows HR13.065 for HIV state at p = 0.000 with CI (4.144-41.191), hospitalization shows HR 16.777 at p = 0.000 at CI (3.676-76.573). Survival analysis was significant by log-rank to Anti-TB started after 90 days of ART initiation HR 10.025 at p = 0.004 at CI (2.082-48.275), and hospitalization at p = 0.01 hospitalization was significantly associated with HIV infection by Fisher exact test p = 0.000.
CONCLUSION: HIV state and time of ATT initiation major cause of death in TB pediatric cases in Tripoli University Hospital.